DNA analysis for donor screening of Dombrock blood group antigens
نویسندگان
چکیده
منابع مشابه
Genetics of the Dombrock blood group system.
In April I965, anti-Doa, an antibody defining a 'new' red cell antigen, was reported (Swanson, Polesky, Tippett, and Sanger, I965). The present paper records the results of tests with anti-Doa on samples received in this unit from October I964 until April I966. Anti-Doa reacts best by the antiglobulin test on papainized cells, but only a minority of otherwise good antiglobulin sera are suitable...
متن کاملComplexities of the Dombrock blood group system revealed.
The Do(a) antigen was discovered after I began my career in immunohematology and I have been fortunate to be involved in several fascinating discoveries in the Dombrock blood group system. The Do(a) antigen and its antithetical antigen, Do(b), have a prevalence that makes them useful as genetic markers. The paucity of reliable anti-Do(a) and anti-Do(b) has prevented this potential from being re...
متن کاملThe value of DNA analysis for antigens of the Kell and Kx blood group systems.
K ell is a major human blood group system that is highly polymorphic, and at present it is known to express 28 different alloantigens. After the ABO and Rh systems, Kell is the most important blood group system in transfusion medicine, as some of the antigens are potent immunogens and their antibodies can cause severe transfusion reactions in mismatched blood transfusions and fetal anemia in fe...
متن کاملThe Dombrock system: linkage relations with other blood group loci.
The recognition of the blood group system called Dombrock was reported in 1965 by Swanson and her colleagues. In 1967 Tippett gave an account of the genetics of the system which included an analysis of the linkage relations of the Do locus to other blood group loci, based on families tested in the MRC Blood Group Unit up to April 1966. The present account brings the linkage analysis up to the e...
متن کاملPrevalence of Rh, Duffy, Kell, Kidd & MNSs blood group antigens in the Indian blood donor population
BACKGROUND & OBJECTIVES Little data are available regarding the frequencies of the blood group antigens other than ABO and RhD in the Indian population. Knowledge of the antigen frequencies is important to assess risk of antibody formation and to guide the probability of finding antigen-negative donor blood, which is especially useful when blood is required for a patient who has multiple red ce...
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ژورنال
عنوان ژورنال: Immunohematology
سال: 2020
ISSN: 0894-203X,1930-3955
DOI: 10.21307/immunohematology-2019-480